{"id":10815,"date":"2022-10-13T12:50:58","date_gmt":"2022-10-13T11:50:58","guid":{"rendered":"https:\/\/fei-online.com\/?p=10815"},"modified":"2022-10-13T12:50:58","modified_gmt":"2022-10-13T11:50:58","slug":"study-suggests-possible-link-between-artificial-sweeteners-and-heart-disease","status":"publish","type":"post","link":"https:\/\/fei-online.com\/study-suggests-possible-link-between-artificial-sweeteners-and-heart-disease\/","title":{"rendered":"Study suggests possible link between artificial sweeteners and heart disease"},"content":{"rendered":"<div id='av_section_1'  class='avia-section main_color avia-section-default avia-no-border-styling  avia-bg-style-scroll  avia-builder-el-0  avia-builder-el-no-sibling   container_wrap fullsize' style=' '  ><div class='container' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-10815'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_one_fifth  flex_column_div av-zero-column-padding first  avia-builder-el-1  el_before_av_three_fifth  avia-builder-el-first  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p style=\"text-align: center\"><div id=\"ads-slider-28\" class=\"custom-slider ads-slider-1417198318 ads-slider\"><ul><li><!--Begin ClixTrac.com Banner Code -->\r\n<a href=\"https:\/\/clixtrac.com\/goto\/?308404\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/clixtrac.com\/banner\/308404.jpg\" alt=\"Free from food\" title=\"Free from food\" border=\"0\" \/><\/a>\r\n<!--End ClixTrac.com Banner Code --><\/li><li><!--Begin ClixTrac.com Banner Code -->\r\n<a href=\"https:\/\/clixtrac.com\/banner\/click.php?banner=302805\" target=\"_blank\" rel=\"noopener\">\r\n<img decoding=\"async\" src=\"https:\/\/clixtrac.com\/banner\/302805.jpg\" alt=\"LUBRIPLATE\" title=\"LUBRIPLATE\" border=\"0\" width=\"120\" height=\"600\" \/><\/a>\r\n<!--End ClixTrac.com Banner Code --><\/li><li><div style=\"margin-left: auto; margin-right: auto; text-align: center; \" id=\"ads-6033564\"><!--Begin ClixTrac.com Banner Code -->\r\n<a href=\"https:\/\/clixtrac.com\/banner\/click.php?banner=297426\" target=\"_blank\" rel=\"noopener\">\r\n<img decoding=\"async\" width=\"100%\" height=\"auto\" src=\"https:\/\/clixtrac.com\/banner\/297426.jpg\" alt=\"Click here for more information!\" title=\"Click here for more information!\" border=\"0\" \/><\/a>\r\n<!--End ClixTrac.com Banner Code --><\/div><\/li><\/ul><\/div><script>( window.advanced_ads_ready || jQuery( document ).ready ).call( null, function() {var $adsslider1417198318 = jQuery( \".ads-slider-1417198318\" );$adsslider1417198318.on( \"unslider.ready\", function() { jQuery( \"div.custom-slider ul li\" ).css( \"display\", \"block\" ); });$adsslider1417198318.unslider({ delay:5000, autoplay:true, nav:false, arrows:false, infinite:true });$adsslider1417198318.on(\"mouseover\", function(){$adsslider1417198318.unslider(\"stop\");}).on(\"mouseout\", function() {$adsslider1417198318.unslider(\"start\");});});<\/script><\/p>\n<\/div><\/section><\/div><div class=\"flex_column av_three_fifth  flex_column_div av-zero-column-padding   avia-builder-el-3  el_after_av_one_fifth  el_before_av_one_fifth  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p style=\"text-align: center\"><\/p>\n<\/div><\/section><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><header class=\"entry-content-header\"><h1 class=\"post-title entry-title\" itemprop=\"headline\">Study suggests possible link between artificial sweeteners and heart disease<\/h1><span class=\"post-meta-infos\">\/ <span class=\"blog-categories minor-meta\">in <a href=\"https:\/\/fei-online.com\/category\/e-news\/\" rel=\"tag\">E-News<\/a> <\/span><\/span><\/header>\n<\/div><\/section><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3>A large study of French adults published by <strong><i><span style=\"font-family: 'Avenir Book'\">The BMJ<\/span><\/i><\/strong> [1] suggests a potential direct association between higher artificial sweetener consumption and increased cardiovascular disease risk, including heart attack and stroke.<\/h3>\n<p><!--more--><\/p>\n<p><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">The findings indicate that these food additives, consumed daily by millions of people and present in thousands of foods and drinks, should not be considered a healthy and safe alternative to sugar, in line with the current position of several health agencies.<\/span><\/p>\n<p><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">Artificial sweeteners are widely used as no or low calorie alternatives to sugar. They represent a US$7.2 billion global market and are found in thousands of products worldwide, particularly ultra-processed foods such as artificially sweetened drinks, some snacks, and low calorie ready meals.<\/span><\/p>\n<p><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">Several studies have linked consumption of artificial sweeteners or artificially sweetened beverages (ASB) to weight gain, high blood pressure, and inflammation, but findings remain mixed about the role of artificial sweeteners in the cause of various diseases, including cardiovascular disease (CVD). What&#8217;s more, several observational studies have used ASB consumption as a proxy to explore CVD risk, but none have measured artificial sweetener intake from the overall diet.<\/span><\/p>\n<p><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">To investigate this further, a team of researchers at the French National Institute for Health and Medical Research (Inserm) and colleagues, drew on data for 103,388 participants (average age 42 years; 80% female) of the web based NutriNet-Sant\u00e9 study, launched in France in 2009 to investigate relations between nutrition and health.<\/span><\/p>\n<p><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">Dietary intakes and consumption of artificial sweeteners were assessed by repeated 24-hour dietary records and a range of potentially influential health, lifestyle, and sociodemographic factors were taken into account.<\/span><\/p>\n<p><b><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">All artificial sweeteners analysed<\/span><\/b><\/p>\n<p><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">Artificial sweeteners from all dietary sources (beverages, table top sweeteners, dairy products, etc) and by type (aspartame, acesulfame potassium, and sucralose) were included in the analysis.\u00a0<\/span><\/p>\n<p><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">A total of 37% of participants consumed artificial sweeteners, with an average intake of 42.46 mg\/day, which corresponds to approximately one individual packet of table top sweetener or 100 mL of diet soda.<\/span><\/p>\n<p><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">Among participants who consumed artificial sweeteners, mean intakes for lower and higher consumer categories were 7.46 and 77.62 mg\/ day, respectively.<\/span><\/p>\n<p><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">Compared with non-consumers, higher consumers tended to be younger, have a higher body mass index, were more likely to smoke, be less physically active, and to follow a weight loss diet. They also had lower total energy intake, and lower alcohol, saturated and polyunsaturated fats, fibre, carbohydrate, fruit and vegetable intakes, and higher intakes of sodium, red and processed meat, dairy products, and beverages with no added sugar. However, the researchers took account of these differences in their analyses.<\/span><\/p>\n<p><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">During an average follow-up period of nine years, 1,502 cardiovascular events occurred. They included heart attack, angina, angioplasty (a procedure to widen blocked or narrowed arteries to the heart), transient ischemic attack and stroke.<\/span><\/p>\n<p><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">The researchers found that total artificial sweetener intake was associated with an increased risk of cardiovascular disease (absolute rate 346 per 100,000 person years in higher consumers and 314 per 100,000 person years in non-consumers).<\/span><\/p>\n<p><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">Artificial sweeteners were more particularly associated with cerebrovascular disease risk (absolute rates 195 and 150 per 100,000 person years in higher and non-consumers, respectively).<\/span><\/p>\n<p><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">Aspartame intake was associated with increased risk of cerebrovascular events (186 and 151 per 100,000 person years in higher and non-consumers, respectively), while acesulfame potassium and sucralose were associated with increased coronary heart disease risk (acesulfame potassium: 167 and 164 per 100,000 person years; sucralose: 271 and 161 per 100,000 person years in higher and non-consumers, respectively).<\/span><\/p>\n<p><b><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">Observational study<\/span><\/b><\/p>\n<p><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">This is an observational study, so can\u2019t establish cause, nor can the researchers rule out the possibility that other unknown (confounding) factors might have affected their results.<\/span><\/p>\n<p><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">Nevertheless, this was a large study that assessed individuals\u2019 artificial sweetener intake using precise, high quality dietary data, and the findings are in line with other studies linking exposure to artificial sweeteners with several markers of poor health.<\/span><\/p>\n<p><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">As such, the researchers say their results suggest no benefit from substituting artificial sweeteners for added sugar on CVD outcomes.<\/span><\/p>\n<p><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">Further prospective cohort studies need to confirm these results and experimental studies are needed to clarify biological pathways, they add.\u00a0<\/span><\/p>\n<p><span lang=\"EN-ZA\" style=\"font-size: 11.0pt;font-family: 'Avenir Book'\">In the meantime, they suggest this study provides key insights into the context of artificial sweetener re-evaluation currently being carried out by the European Food Safety Authority, the World Health Organization, and other health agencies.<\/span><\/p>\n<\/div><\/section><br \/>\n<div  class='avia-image-container  av-styling-    avia-builder-el-7  el_after_av_textblock  el_before_av_textblock  avia-align-center '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img class='avia_image' src='https:\/\/fei-online.com\/wp-content\/uploads\/sites\/4\/2022\/10\/artificial-sweetener-scaled.jpg' alt='' title='SONY DSC' height=\"1011\" width=\"2560\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p><strong><em>Reference:<\/em><\/strong><\/p>\n<ol>\n<li><strong><em>Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Sant\u00e9 cohort. 7 Sept 2022. doi: <a href=\"https:\/\/doi.org\/10.1136\/bmj-2022-071204\">https:\/\/doi.org\/10.1136\/bmj-2022-071204<\/a><\/em><\/strong><\/li>\n<\/ol>\n<\/div><\/section><br \/>\n<div  class='av-social-sharing-box  avia-builder-el-9  el_after_av_textblock  avia-builder-el-last  av-social-sharing-box-minimal '><div class='av-share-box'><h5 class='av-share-link-description av-no-toc '>Share this<\/h5><ul class='av-share-box-list noLightbox'><li class='av-share-link av-social-link-facebook' ><a target=\"_blank\" aria-label=\"Share on Facebook\" href='https:\/\/www.facebook.com\/sharer.php?u=https:\/\/fei-online.com\/study-suggests-possible-link-between-artificial-sweeteners-and-heart-disease\/&#038;t=Study%20suggests%20possible%20link%20between%20artificial%20sweeteners%20and%20heart%20disease' aria-hidden='false' data-av_icon='\ue8f3' data-av_iconfont='entypo-fontello' title='' data-avia-related-tooltip='Share on Facebook' rel=\"noopener\"><span class='avia_hidden_link_text'>Share on 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