{"id":9669,"date":"2021-04-28T14:46:17","date_gmt":"2021-04-28T13:46:17","guid":{"rendered":"https:\/\/fei-online.com\/?p=9669"},"modified":"2021-05-05T14:55:59","modified_gmt":"2021-05-05T13:55:59","slug":"new-research-findings-could-improve-the-biomanufacturing-of-vitamin-b12","status":"publish","type":"post","link":"https:\/\/fei-online.com\/new-research-findings-could-improve-the-biomanufacturing-of-vitamin-b12\/","title":{"rendered":"New research findings could improve the biomanufacturing of vitamin B12"},"content":{"rendered":"<div id='av_section_1'  class='avia-section main_color avia-section-default avia-no-border-styling  avia-bg-style-scroll  avia-builder-el-0  avia-builder-el-no-sibling   container_wrap fullsize' style=' '  ><div class='container' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-9669'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_one_fifth  flex_column_div av-zero-column-padding first  avia-builder-el-1  el_before_av_three_fifth  avia-builder-el-first  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p style=\"text-align: center;\"><div id=\"ads-slider-28\" class=\"custom-slider ads-slider-258032582 ads-slider\"><ul><li><!--Begin ClixTrac.com Banner Code -->\r\n<a href=\"https:\/\/clixtrac.com\/goto\/?308404\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/clixtrac.com\/banner\/308404.jpg\" alt=\"Free from food\" title=\"Free from food\" border=\"0\" \/><\/a>\r\n<!--End ClixTrac.com Banner Code --><\/li><li><!--Begin ClixTrac.com Banner Code -->\r\n<a href=\"https:\/\/clixtrac.com\/banner\/click.php?banner=302805\" target=\"_blank\" rel=\"noopener\">\r\n<img decoding=\"async\" src=\"https:\/\/clixtrac.com\/banner\/302805.jpg\" alt=\"LUBRIPLATE\" title=\"LUBRIPLATE\" border=\"0\" width=\"120\" height=\"600\" \/><\/a>\r\n<!--End ClixTrac.com Banner Code --><\/li><li><div style=\"margin-left: auto; margin-right: auto; text-align: center; \" id=\"ads-1597459340\"><!--Begin ClixTrac.com Banner Code -->\r\n<a href=\"https:\/\/clixtrac.com\/banner\/click.php?banner=297426\" target=\"_blank\" rel=\"noopener\">\r\n<img decoding=\"async\" width=\"100%\" height=\"auto\" src=\"https:\/\/clixtrac.com\/banner\/297426.jpg\" alt=\"Click here for more information!\" title=\"Click here for more information!\" border=\"0\" \/><\/a>\r\n<!--End ClixTrac.com Banner Code --><\/div><\/li><\/ul><\/div><script>( window.advanced_ads_ready || jQuery( document ).ready ).call( null, function() {var $adsslider258032582 = jQuery( \".ads-slider-258032582\" );$adsslider258032582.on( \"unslider.ready\", function() { jQuery( \"div.custom-slider ul li\" ).css( \"display\", \"block\" ); });$adsslider258032582.unslider({ delay:5000, autoplay:true, nav:false, arrows:false, infinite:true });$adsslider258032582.on(\"mouseover\", function(){$adsslider258032582.unslider(\"stop\");}).on(\"mouseout\", function() {$adsslider258032582.unslider(\"start\");});});<\/script><\/p>\n<\/div><\/section><\/div><div class=\"flex_column av_three_fifth  flex_column_div av-zero-column-padding   avia-builder-el-3  el_after_av_one_fifth  el_before_av_one_fifth  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p style=\"text-align: center;\"><\/p>\n<\/div><\/section><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><header class=\"entry-content-header\"><h1 class=\"post-title entry-title\" itemprop=\"headline\">New research findings could improve the biomanufacturing of vitamin B12<\/h1><span class=\"post-meta-infos\">\/ <span class=\"blog-categories minor-meta\">in <a href=\"https:\/\/fei-online.com\/category\/featured-articles\/\" rel=\"tag\">Featured Articles<\/a> <\/span><\/span><\/header>\n<\/div><\/section><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>Vitamin B12 is an essential micronutrient which plays a role in supporting red blood cell production, energy, metabolism and nerve function, however it is neither made, nor required by plants.<\/p>\n<p><!--more--><\/p>\n<p>With a record 560,000 people signing up to Veganuary 2021, this important nutrient is in demand and the global transition to low-meat diets means that biomanufacturing will need to increase. However, due to its complex molecular structure, it is currently not feasible to mass-produce via conventional chemical synthesis.<\/p>\n<p>Instead, it is the only vitamin which is produced exclusively by bioproduction (culturing bacteria that naturally produce B12). This process remains inefficient and it continues to be expensive for many people who need it \u2013 particularly in developing nations. New research, by Dr Tessa Young, of the Department of Biosciences, Durham University, UK, published in Nature Communications, looked into ways of understanding and improving the biosynthesis of B12 by studying how enzymes obtain essential metals.<\/p>\n<p>With cobalt a crucial metal in the B12 production process, Dr Young and the Durham team worked closely with Professor Martin Warren of the University of Kent and the Quadram Institute in Norwich, whose research group engineered E. Coli strains (which don\u2019t normally make B12) to synthesise the vitamin.<\/p>\n<p>During vitamin B12 biomanufacturing, the vital element, cobalt, is supplied by a metal delivery enzyme. However, ensuring that this enzyme is supplying enough of the right metal, and not becoming clogged-up with the wrong one, remains an obstacle when producing B12 on a large scale.<\/p>\n<p>Prof Warren explained: \u201cUnderstanding more about cobalt delivery not only helps improve the biosynthetic process but also means that the cobalt is used more efficiently, reducing environmental pollution.\u201d To overcome the cobalt bottleneck, Dr Young and the Durham team created a \u2018metalation calculator\u2019 to understand and optimise cobalt supply for B12 to support the manufacture of this essential vitamin.<\/p>\n<p>Dr Young explained: \u201cBy understanding the mechanism that distributes vital metals, it has become possible to produce a calculator which industrial biotechnologists can use to optimise their manufacturing reactions. \u201cThe calculator has been tested in the production of vitamin B12 and we hope to see it adopted by biotechnology manufacturers to help foster a more sustainable future.\u201d<\/p>\n<p>Senior author Professor Nigel Robinson, in the Department of Biosciences, Durham University, said: \u201cAbout a half of life\u2019s reactions are catalysed by metals including iron, copper, zinc, magnesium, manganese, nickel and cobalt.<\/p>\n<p>\u201cThis paper describes the underlying mechanism that distributes these metals to the reaction centres inside living cells. Industrial Biotechnology manufactures compounds that society needs sustainably, by replacing processes that use fossil fuels with yeast, bacteria or the cells of other organisms as the alternative factories.\u201d<\/p>\n<p>The ability of the \u2018metalation calculator\u2019 to determine the metal requirements for producing B12 on a large scale shows great promise, not only for the manufacturing of this supplement but also in wider sustainable manufacturing processes using biotechnology.<\/p>\n<p>\u201cOur studies are not only investigating how B12 synthesis can be improved but at the same time they are looking at how we can reduce the levels of cobalt that are used in the process, since cobalt by itself is toxic\u201d said Prof. Warren.<\/p>\n<\/div><\/section><br \/>\n<div   class='hr hr-default   avia-builder-el-7  el_after_av_textblock  el_before_av_textblock '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3>References<\/h3>\n<p>Calculating metalation in cells reveals CobW acquires CoII for vitamin B12 biosynthesis while related proteins prefer ZnII (Nature Communications). Doi: <a href=\"http:\/\/dx.doi.org\/10.1038\/s41467-021-21479-8\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/dx.doi.org\/10.1038\/s41467-021-21479-8<\/a><\/p>\n<\/div><\/section><br \/>\n<div  class='av-social-sharing-box  avia-builder-el-9  el_after_av_textblock  avia-builder-el-last  av-social-sharing-box-minimal '><div class='av-share-box'><h5 class='av-share-link-description av-no-toc '>Share this<\/h5><ul class='av-share-box-list noLightbox'><li class='av-share-link av-social-link-facebook' ><a target=\"_blank\" aria-label=\"Share on Facebook\" href='https:\/\/www.facebook.com\/sharer.php?u=https:\/\/fei-online.com\/new-research-findings-could-improve-the-biomanufacturing-of-vitamin-b12\/&#038;t=New%20research%20findings%20could%20improve%20the%20biomanufacturing%20of%20vitamin%20B12' aria-hidden='false' data-av_icon='\ue8f3' data-av_iconfont='entypo-fontello' title='' data-avia-related-tooltip='Share on Facebook' rel=\"noopener\"><span class='avia_hidden_link_text'>Share on Facebook<\/span><\/a><\/li><li class='av-share-link av-social-link-twitter' ><a target=\"_blank\" aria-label=\"Share on Twitter\" href='https:\/\/twitter.com\/share?text=New%20research%20findings%20could%20improve%20the%20biomanufacturing%20of%20vitamin%20B12&#038;url=https:\/\/fei-online.com\/?p=9669' aria-hidden='false' data-av_icon='\ue8f1' data-av_iconfont='entypo-fontello' title='' data-avia-related-tooltip='Share on Twitter' rel=\"noopener\"><span class='avia_hidden_link_text'>Share on Twitter<\/span><\/a><\/li><li class='av-share-link av-social-link-whatsapp' ><a target=\"_blank\" aria-label=\"Share on WhatsApp\" href='https:\/\/api.whatsapp.com\/send?text=https:\/\/fei-online.com\/new-research-findings-could-improve-the-biomanufacturing-of-vitamin-b12\/' aria-hidden='false' data-av_icon='\uf232' data-av_iconfont='entypo-fontello' title='' data-avia-related-tooltip='Share on WhatsApp' rel=\"noopener\"><span class='avia_hidden_link_text'>Share on WhatsApp<\/span><\/a><\/li><li class='av-share-link av-social-link-linkedin' ><a target=\"_blank\" aria-label=\"Share on LinkedIn\" href='https:\/\/linkedin.com\/shareArticle?mini=true&#038;title=New%20research%20findings%20could%20improve%20the%20biomanufacturing%20of%20vitamin%20B12&#038;url=https:\/\/fei-online.com\/new-research-findings-could-improve-the-biomanufacturing-of-vitamin-b12\/' aria-hidden='false' data-av_icon='\ue8fc' data-av_iconfont='entypo-fontello' title='' data-avia-related-tooltip='Share on LinkedIn' rel=\"noopener\"><span class='avia_hidden_link_text'>Share on LinkedIn<\/span><\/a><\/li><li class='av-share-link av-social-link-mail' ><a  aria-label=\"Share by Mail\" href='mailto:?subject=New%20research%20findings%20could%20improve%20the%20biomanufacturing%20of%20vitamin%20B12&#038;body=https:\/\/fei-online.com\/new-research-findings-could-improve-the-biomanufacturing-of-vitamin-b12\/' aria-hidden='false' data-av_icon='\ue805' data-av_iconfont='entypo-fontello' title='' data-avia-related-tooltip='Share by Mail'><span class='avia_hidden_link_text'>Share by Mail<\/span><\/a><\/li><\/ul><\/div><\/div><\/p><\/div><div class=\"flex_column av_one_fifth  flex_column_div av-zero-column-padding   avia-builder-el-10  el_after_av_three_fifth  avia-builder-el-last  \" style='border-radius:0px; 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