PhytoGaia highlights tocotrienol potential for cognitive health applications
Two recent scoping reviews have reinforced the scientific evidence supporting tocotrienols as neuroprotective agents, positioning the palm-derived vitamin E compounds as promising ingredients for brain health formulations.
The first review, led by researchers from the National University of Malaysia, was conducted using the Arksey and O’Malley framework and PRISMA-ScR guidelines. By systematically searching PubMed, Scopus and Web of Science, the team identified and analysed 24 eligible articles of experimental studies to evaluate the neuroprotective effects of tocotrienols on the brain.
Multiple protective mechanisms identified
The findings revealed that tocotrienols exert multiple unique protective mechanisms, including antioxidant and anti-inflammatory effects through reducing oxidative stress, lipid peroxidation and inflammatory markers; regulation of gene and protein expression by modulating key molecular pathways linked to stroke-induced injuries, brain health and resilience; enhancement of memory and cognitive function by supporting learning, memory and behavioural performance in ageing and neurodegeneration models; and pre-servation of cell and organelle morphology through protecting neuronal structure and maintaining mitochondrial integrity.
A second review, published in June 2025, compared the distinct roles of tocopherols and tocotrienols in brain health. The authors highlighted that although α-tocopherol remains the most widely studied, tocotrienols show stronger anti-inflammatory and antioxidative capacities and hold promise in preserving white matter integrity and modulating neurodegenerative pathways.
Significantly enhanced potency
The research underscores tocotrienols’ superior bioactivity compared to conventional vitamin E. Tocotrienol’s antioxidant and neuroprotective activities have been reported to be 40–60 and 1000 times more potent, respectively, than regular vitamin E tocopherol.
Clinical validation and future research
Dr Ariati Aris, Scientific Affairs Specialist at PhytoGaia, commented: “Backed by growing scientific evidence, tocotrienols are emerging as promising neuroprotective agents that support and protect brain cells, cognitive functions and memory as well as healthier ageing. A recently published clinical study shows that TocoGaia enhances psychological well-being, modulates oxidative stress and supports genomic stability in ageing populations.”
“Building on this, we are now planning a new randomised-controlled trial with TocoGaia for cognitive health, which we believe will further validate tocotrienols’ role as next-generation brain phytonutrient,” added Dr Aris.
Commercial opportunities
Bryan See, Vice President of PhytoGaia, said: “For our partners and brand owners, TocoGaia offers a unique opportunity to differentiate their formulations with a next-generation vitamin E that delivers more than conventional tocopherols. With the latest science reinforcing tocotrienols’ potent neuroprotective potential, TocoGaia is the perfect ingredient for companies looking to innovate and create value in areas such as brain and cognitive health, healthy ageing and functional nutrition.”
For more information, visit: https://www.phytogaia.com
